Comparative efficacy of disease-modifying therapies for patients with relapsing remitting multiple sclerosis: Systematic review and network meta-analysis
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- 作者：Emer Fogartya ; efogarty@stjames.ie" class="auth_mail" title="E-mail the corresponding author ; Susanne Schmitzb ; Niall Tubridyc ; Cathal Walshd ; Michael Barrye
- 关键词：Network meta-analysis ; Systematic review ; Disease-modifying therapy ; Multiple sclerosis ; Disability progression ; Relapse
- 刊名：Multiple Sclerosis and Related Disorders
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：23-30
- 全文大小：1316 K
文摘
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Comparative efficacy of disease-modifying therapies in relapsing remitting multiple sclerosis was evaluated.
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A systematic review and network meta-analysis of 26 randomised controlled trials was conducted.
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Reductions in annualised relapse rate ranged from 15 to 69%, and from 19 to 68% in disability progression.
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The magnitude of reductions varied between DMTs with variation in outcome definition leading to variation in treatment rankings.