Fragment-based methods for the discovery of inhibitors modulating lysyl-tRNA synthetase and laminin receptor interaction

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• 作者：Hye Young Cho^a ; Sunghoon Kim^b ; ^c ; ^{sungkim@snu.ac.kr} ; Young Ho Jeon^a ; ^{yhjeon@korea.ac.kr}
• 关键词：Lysyl-tRNA synthetase ; Laminin receptor ; Cancer metastasis ; Protein&ndash ; protein interaction ; Fragment-based drug discovery ; Nuclear magnetic resonance (NMR)
• 刊名：Methods
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：113
• 期：Complete
• 页码：56-63
• 全文大小：1459 K
• 卷排序：113

文摘

Modulation of lysyl-tRNA synthetase–laminin receptor interaction inhibits metastasis. Hot-spot residues of lysyl-tRNA synthetase were identified based on the NMR analyses. NMR-based fragment screening methods can be exploited to discover inhibitors.