Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus

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• 作者：Cecí ; lia Cerqueira Café ; -Mendes^a ; ^b ; Humberto Miguel Garay-Malpartida^c ; Marí ; lia Brinati Malta^d ; Larrissa de Sá ; Lima^d ; Cristó ; foro Scavone^d ; Zulma S. Ferreira^e ; Regina P. Markus^e ; Tania Marcourakis^a ; ^{tmarcour@usp.br}
• 关键词：Nicotine ; LPS ; NF-κB ; α7 nicotinic acetylcholine receptors ; Hippocampus ; TLR-4
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：218-224
• 全文大小：1420 K
• 卷排序：636

文摘

Chronic nicotine administration inhibited the nuclear binding of NF-κB. Chronic nicotine inhibited the NF-κB-regulated mRNA expression of Tnf, Il1b, Nos2, and Tlr4. Chronic treatment with methyllycaconitine and mecamylamine inhibited the effects of nicotine on the LPS-induced activation of NF-κB. nAChRs are potential targets for modulating antiinflammatory responses in the brain.