Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor
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- 作者：Christian Bjerregaard-Olesen ; cbjr@ph.au.dk" class="auth_mail" title="E-mail the corresponding author ; Mandana Ghisari ; Lisbeth S. Kjeldsen ; Maria Wielsø ; e ; Eva C. Bonefeld-Jø ; rgensen
- 关键词：AR ; androgen receptor ; DC ; dextran/charcoal ; DHEA ; dehydroepiandrosterone ; DHEAS ; dehydroepiandrosterone sulfate ; DHT ; dihydrotestosterone ; E1 ; estrone ; E1S ; estrone sulfate ; E2 ; 17β-estradiol ; ER ; estrogen receptor ; FCS ; fetal calf serum ; HF ; hydroxyflutamide ; LDH ; lactate dehydrogenase ; LOEC ; lowest observed effect concentration ; MOEC ; maximum observed effect concentration ; PFAA ; perfluorinated alkyl acid ; STS ; steroid sulfatase
- 刊名：Steroids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：50-58
- 全文大小：1749 K
文摘
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Estrone sulfate transactivate the estrogen and androgen receptor dose-dependently.
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Serum PFAA extracts containing sulfated steroids transactivate the AR.
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The AR transactivity of dehydroepiandrosterone sulfate could be blocked by STX64.