Loss of Bin1 Promotes the Propagation of Tau Pathology
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- 作者：Sara Calafate1 ; 2 ; 3 ; William Flavin4 ; Patrik Verstreken2 ; 3 ; 5 ; patrik.verstreken@cme.vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Diederik Moechars1 ; dmoechar@its.jnj.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tau ; spreading ; in vitro model ; BIN1 ; Alzheimer GWAS ; synapse ; endocytosis ; Rab5 ; galectin-3
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：931-940
- 全文大小：3353 K
文摘
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Endocytosis interferes with Tau pathology propagation in culture
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BIN1 is a negative modulator of endocytic flux
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BIN1 levels and propagation of Tau pathology are inversely correlated
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Internalized Tau aggregates permeabilize the membrane of endosomes