Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet
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- 作者：Rishipal R. Bansode ; Priscilla R ; olph ; Steven Hurley ; Mohamed Ahmedna
- 关键词：PE ; peanut skin extract ; WD ; Western diet ; CVD ; cardiovascular diseases ; LDL ; low density lipoprotein ; HDL ; high density lipoprotein ; TC ; total cholesterol ; TG ; triglyceride ; ACC ; acyl CoA carboxylase ; FAS ; fatty acid synthase ; SREBP-1c ; sterol regulatory
- 刊名：Food Chemistry
- 出版年：2012
- 出版时间：1 December, 2012
- 年：2012
- 卷：135
- 期：3
- 页码：1659-1666
- 全文大小：1142 K
文摘
The effect of water soluble polyphenolic extract of peanut skin (PE) was investigated for its hypolipidemic properties in rats on Western diet. Seven-weeks old Wistar rats received control diet (AIN-93G), Western diet with and without a bolus of PE five times a week for 10 weeks. Group which received 300 mg/kg body weight showed significantly reduced body weight and epididymal fat. Plasma and liver triglyceride (TG) and cholesterol (TC) levels were significantly reduced while faecal secretion of TG and TC was greatly increased upon PE administration.
Liver mRNA expression of enzymes involved in fatty acid synthesis, such as fatty acid synthase (FAS), sterol receptor element binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC1) and lipid uptake genes, such as PPAR¦Ã, were decreased, while PPAR¦Á was up-regulated by administration of PE. These data suggest that administration of PE may contribute to the improved lipid homoeostasis in rats on diets high in cholesterol and lipids.