Trihydroxylated linear diterpenes from the brown alga Bifurcaria bifurcata (Fucales, Phaeophyta)
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- 作者：Mohamed El Hattab ; Mohammed Ben Mesaoud ; Mohammed Daoudi ; Annick Ortalo-Magné ; Gé ; rald Culioli ; Robert Valls ; Louis Piovetti
- 关键词：Sargassaceae ; Phaeophyceae ; Bifurcaria bifurcata ; Brown alga ; Trihydroxylated linear diterpenes ; Chemotaxonomy
- 刊名：Biochemical Systematics and Ecology
- 出版年：2008
- 出版时间：May-June 2008
- 年：2008
- 卷：36
- 期：5-6
- 页码：484-489
- 全文大小：164 K
文摘
In this article we attempted to identify whether there is a specific mismatched antigen that might be detrimental to kidney transplant outcome. The frequency of function versus failure of transplant cases was tallied within subpopulations among a subset of the 2006 United Network for Organ Sharing transplant dataset. We examined 7998 cadaveric and 11,420 living donor kidney transplants that were mismatched for a single class I antigen. When tested by five different criteria, the results were relatively similar for the HLA class I, A- and B-locus mismatches. HLA A1 was identified as the single most dominant immunogenic mismatch. However, when the P values were multiplied by 68, the number of comparisons, A1 was only marginally significant. We concluded that at least for class I specificities, the 68 specificities were about equal immunogenicity in kidney transplantation.