Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats
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- 作者：Reem M. Hashem ; Ph.D.a ; b ; r.ahmed29@bradford.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Rasha H. Mohamed ; Ph.D.c ; Dina M. Abo-El-matty ; Ph.D.d
- 关键词：Curcumin ; TNFR1 ; TNFR2 ; TRAF2 ; Caspase 8 ; RIP
- 刊名：Nutrition
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：4
- 页码：478-485
- 全文大小：1927 K
文摘
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Curcumin-rich diet decreased TNF-α and TNFR2 mRNA in UUO rats.
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Curcumin did not affect TNFR1 mRNA and increased the ratio of TNFR1/TNFR2.
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TNFR1 recruits the adaptor TRADD, which binds the RIP and TNFR2 in curcumin group.
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TRADD-RIP-TRAF complex activates the antiapoptotic pathway and inhibits caspase 8.
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Curcumin decreased TNFR2 and increased TRAF2 to decrease the apoptotic pathway.