Generation of a reassortant avian influenza virus H5N2 vaccine strain capable of protecting chickens against infection with Egyptian H5N1 and H9N2 viruses
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- 作者：Ahmed Kandeil<sup>asup> ; Yassmin Moatasim<sup>asup> ; Mokhtar R. Gomaa<sup>asup> ; Mahmoud M. Shehata<sup>asup> ; Rabeh El-Shesheny<sup>asup> ; Ahmed Barakat<sup>csup> ; Richard J. Webby<sup>bsup> ; Mohamed A. Ali<sup>asup><sup> ; sup><sup>mohamedahmedali2004@yahoo.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Ghazi Kayali<sup>bsup><sup> ; sup><sup>ghazi.kayali@stjude.org" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Avian influenza virus ; Reverse genetics ; Vaccine
- 刊名：Vaccine
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：34
- 期：2
- 页码：218-224
- 全文大小：1099 K
文摘
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We showed that the NA of H9N2 was responsible for the high replication rates of Egyptian H9N2 viruses.
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We generated a reassortant vaccine strain incorporating the HA from H5N1 and NA from H9N2 on a PR8 backbone.
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The H5N2 vaccine was efficacious under laboratory and field conditions.