The role of intravenous paracetamol in conscious sedation during Internal Cardioverter Defibrillator (ICD) insertion in geriatric patients

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• 作者：Mohamed A. Khalil^a ; ^{mohamedkhalil404@hotmail.com} ; Abdelhay A. Ebade^a ; Mohsen S. Abdel Azeem^b
• 关键词：Paracetamol ; Fentanyl ; Conscious sedation ; Internal Cardioverter Defibrillator (ICD)
• 刊名：Egyptian Journal of Anaesthesia
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：29
• 期：1
• 页码：41-45
• 全文大小：291 K

文摘

Background

Insertion of Internal Cardioverter Defibrillator in high risk cardiac patients can be performed by many anesthetic techniques including local anesthesia with moderate sedation or general anesthesia. Many studies have proved that intravenous paracetamol infusion is effective in reducing narcotic requirements in many surgical procedures.

Purpose

The aim of this study was to assess the effect of paracetamol in reducing pain as well as apnea and upper airway obstruction during conscious sedation for Internal Cardioverter Defibrillator placement.

Patients and methods

In this prospective, randomized study, 100 patients undergoing elective transvenous placement of Internal Cardioverter Defibrillator (ICD) were enrolled in this study. Pain, respiratory events as apnea and airway obstruction in patients receiving intravenous paracetamol infusion 1 g over 30 min have been compared with those receiving fentanyl in a total dose of 1.5 ¦Ìg/kg.

Results

The incidence of airway obstruction was lower in the paracetamol group than in the fentanyl one (P < 0.05). There was also a significant difference between the two groups as regards arterial carbon dioxide tension (PCO2), which was significantly higher in Group F (48.9 ¡À 0.63) in comparison to Group P (45.6 ¡À 0.64) (P < 0.001) as well as the degree of sedation where the sedation score was 2.2 ¡À 0.3 in group P. Also, the Visual Analog Scale (VAS) was significantly lower in Group P than in Group F (P < 0.05).

Conclusion

Intravenous paracetamol infusion was effective in reducing pain as well as the incidence of intraoperative respiratory events as upper airway obstruction in high risk cardiac patients undergoing Internal Cardioverter Defibrillator insertion.