Long term impact of sulfur mustard exposure on peripheral blood mononuclear subpopulations 鈥?Sardasht-Iran Cohort Study (SICS)

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• 作者：Tooba Ghazanfari ; Amina Kariminia ; Roya Yaraee ; Soghrat Faghihzadeh ; Sussan K. Ardestani ; Massoumeh Ebtekar ; Ali Mostafaie ; Abbas Foroutan ; Abbas Rezaei ; Jalaleddin Shams ; Mahmoud Mahmoudi ; Mohammad R. Vaez-Mahdavi ; Mohammad R. Soroush ; Mohammadreza Jalali-Nadoushan ; Sakine Moaiedmohseni ; Soheila Ajdary ; Hiedeh Darabi ; Mohammad M. Naghizadeh ; Hadi Kazemi ; Zuhair M. Hassan ; et al.
• 关键词：Sulfur mustard ; Pulmonary function ; Leukocyte sub-sets ; NK cells
• 刊名：International Immunopharmacology
• 出版年：November, 2013
• 年：2013
• 卷：17
• 期：3
• 页码：931-935
• 全文大小：179 K

文摘

The most important long-term morbidity problem of sulfur mustard (SM) toxicity is pulmonary complications but the pathogenesis of these complications is not clearly understood. This study evaluates the peripheral blood mononuclear sub-sets and their correlation with pulmonary function in SM exposed civilian cases 20 years post-exposure as gathered in the context of the Sardasht-Iran Cohort Study (SICS). Samples were randomly selected from two groups, SM-exposed (n = 372) and control (n = 128), with the same ethnicity, culture, and demography. Three color flow cytometry was applied for peripheral blood mononuclear sub-population determination. Results indicated a significant decrease in CD45 +/CD3 +, CD45 +/CD3 +/CD4 +, and an increase in CD3 +/CD16+56 + percentages. It was also found that absolute count of NK cells was highly increased in peripheral blood of exposed cases. There was a significant increase in NK cell count of SM exposed group with pulmonary problems as compared to the same group without pulmonary problems (p-value < 0.04) based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD). The findings showed a significant negative correlation between absolute numbers of T lymphocyte and FVC % and positive correlation with FEV1/FVC%. The results also demonstrated that absolute numbers of monocytes had a negative correlation with FVC %. We propose that NK and T cells are probably involved in the pathogenesis or immune reactions to the delayed pulmonary complications induced by SM. This hypothesis should be tested in a more severe pulmonary complicated group.