文摘
Polysubstituted pyridine derivatives were synthesized through economical one-pot multicomponent reactions of different ¦Á,¦Â-unsaturated ketones, malononitrile, and ethanol or methanol in the presence of Amberlite IRA-400 (OH?) at room temperature. The catalyst is recyclable several times without substantial loss of activity. Other valuable features include the wide range of functional group tolerance, easy and clean synthesis with a simple work-up procedure, and excellent yields under mild conditions.