Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis

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• 作者：Mohammad Balood^a ; Hamid Zahednasab^a ; Bahaaddin Siroos^b ; Seyed Alireza Mesbah-Namin^a ; Sara Torbati^b ; Mohammad Hossein Harirchian^b ; ^{harirchm@sina.tums.ac.ir" class="auth_mail}
• 刊名：Human Immunology
• 出版年：May, 2014
• 年：2014
• 卷：75
• 期：5
• 页码：411-413
• 全文大小：397 K

文摘

A plethora of studies have shown that lysophosphatidic acid (LPA) is involved both in inflammation and T cell apoptosis evasion. The aim of this study was to measure the concentrations of LPA in serum of patients with multiple sclerosis (MS). Twenty MS patients along with 20 age-sex matched healthy individuals were recruited for this investigation. By employment of ELISA method, we demonstrated that MS patients had higher levels of LPA in serum than control group (P = 0.006). This study is the first report of LPA elevation in MS disease.