Adaptive Optics Imaging of Retinal Photoreceptors Overlying Lesions in White Dot Syndrome and its Functional Correlation

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• 作者：Aniruddha AgarwalAuthor Vitae ; Mohamed Kamel Soliman ; Mostafa Hanout ; Mohammad Ali Sadiq ; Salman Sarwar ; Loren S. Jack ; Diana V. Do ; Quan Dong Nguyen ; Yasir J. Sepah ; ^{yjs@oirrc.net" class="auth_mail" title="E-mail the corresponding author} ; ^{yasir.sepah@unmc.edu" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 刊名：American Journal of Ophthalmology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：160
• 期：4
• 页码：806-816.e2
• 全文大小：4894 K

文摘

To quantify retinal photoreceptor density using adaptive optics (AO) imaging and correlate it with retinal tomography, fundus autofluorescence, and retinal sensitivity overlying lesions in various white dot syndromes (WDS).

Design

Prospective cross-sectional study.

Methods

setting: Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA. study population: Thirty-five lesions of WDS from 12 patients (19 eyes; mean age: 54.4 ± 15.8 years; 9 female) were analyzed. intervention: Macular lesions (≤3 regions of interest/eye), at 2 fixed eccentric loci, were imaged using AO, spectral-domain optical coherence tomography, and fundus autofluorescence. In this study, lesions were defined as active if there was presence of hyperautofluorescence within the lesions. Photoreceptor density was calculated after manual correction and adjustment for axial length. Retinal sensitivity was assessed using microperimetry and correlated with photoreceptor density using Spearman rank correlation test. outcome measures: Mean retinal sensitivity and photoreceptor density at the WDS lesions.

Results

Mean photoreceptor density was 7331 ± 4628 cones/mm² overlying 16 active lesions and 6546 ± 3775 cones/mm² overlying 19 inactive lesions (P = .896). Mean retinal sensitivity (9.37 ± 5.34 dB) showed modest correlation with photoreceptor density (蟻 = 0.42, P = .03). Retinal sensitivity over lesions with intact inner segment-outer segment (IS-OS) junction was 13.35 ± 3.75 dB and 6.33 ± 4.31 dB over lesions with disrupted IS-OS junction (P = .005).

Conclusions

AO imaging may allow high-resolution analysis of photoreceptor loss among lesions in WDS. Such microstructural changes may correlate with functional loss.