Amino acid-based enantiomerically pure 3-substituted 1,4-benzodiazepin-2-ones: A new class of anti-ischemic agents

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• 作者：Jitendra Kumar Mishra ; Puja Garg ; Preeti Dohare ; Ashutosh Kumar ; Mohammad Imran Siddiqi ; Madhur Ray ; Gautam P ; a
• 关键词：Anti-ischemic agents ; 1 ; 4-Benzodiazepin-2-ones ; Amino acids
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 出版时间：1 March 2007
• 年：2007
• 卷：17
• 期：5
• 页码：1326-1331
• 全文大小：761 K

文摘

A series of 3-substituted 1, 4-benzodiazepin-2-ones derived from S and R amino acids were evaluated for their anti-ischemic activity in vitro. Treatment with compounds 7h, 16, 9d, and 17 decreased the apoptotic neuronal number, however increased the neuronal viability. The compounds decreasing apoptosis could protect neurons from the ischemic injury. The difference in the activities of 1,4-benzodiazepin-2-ones derived from S- and R-amino acids is discussed and explained on the basis of molecular modeling studies.