Resveratrol treatment attenuates chemokine receptor expression in the BTBR T + tf/J mouse model of autism

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• 作者：Saleh A. Bakheet^a ; Mohammad Zeed Alzahrani^a ; Ahmed Nadeem^a ; Mushtaq Ahmad Ansari^a ; Khairy M A Zoheir^a ; ^b ; Sabry M. Attia^a ; ^c ; Laila Yousef AL-Ayadhi^d ; Sheikh Fayaz Ahmad^a ; ^{s_fayazahmad@yahoo.com} ; ^{fashaikh@ksu.edu.sa}
• 关键词：Autism ; Resveratrol ; BTBR T  ; +  ; tf/J ; C57BL/6J ; CCR and CXCR ; Spleen ; Brain
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：77
• 期：Complete
• 页码：1-10
• 全文大小：2527 K
• 卷排序：77

文摘

Expression of CCR receptors is elevated in BTBR autistic mice. Expression of the CXCR receptors is increased in BTBR autistic mice. Resveratrol treatment decreased both CCR and CXCR receptors in autistic mice. Chemokine receptor downregulation may be a therapeutic option for treating autism.