- 作者：Seyed-Farzad Mohammadi ; MD ; FICO ; Elham Ashrafi ; MSc ; PhD ; el.ashrafi@gmail.com" class="auth_mail ; Nima Norouzi ; MD ; Tahereh Abdolahinia ; MSc ; Mohsen Mir-AbouTalebi ; BSc ; Mahmoud Jabbarvand ; MD
- 刊名：Journal of Cataract and Refractive Surgery
- 出版年：June 2014
- 年：2014
- 卷：40
- 期：6
- 页码：937-942
- 全文大小：198 K
Setting
Refractive Surgery Unit, Farabi Eye Hospital, Tehran, Iran.
Design
Double-masked randomized clinical trial.
Methods
In patients with spherical equivalent myopia of −0.75 to −3.87 diopters (D) and astigmatism up to −1.75 D, the first eye was randomly assigned to the application of MMC 0.02% or a balanced salt solution for 15 seconds. The fellow eye received the alternate in a masked fashion after excimer photoablation.
Results
The study enrolled 60 patients. In fellow eyes, the changes in the tear-film index were comparable 1 month and 6 months postoperatively. There was no significant difference in changes in total higher-order aberrations, spherical aberration, coma, or Q values (Pentacam HR) between fellow eyes at 1 month and 6 months. There was a trend toward a higher asymmetry index at 1 month; however, a statistically significant drop was observed at 6 months in the MMC group (P<.01). It was hypothesized that stromal remodeling was delayed, but better, in MMC-treated eyes. No haze was recorded at 6 months in either group.
Conclusion
Use of MMC in PRK did not appear to contribute significantly to surface irregularity, transient tear-film dysfunction, or biomechanical weakening of the cornea compared with PRK without MMC.
Financial Disclosure
No author has a financial or proprietary interest in any material or method mentioned.