Genetic association study of P2x7 A1513C (rs 3751143) polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis based on the findings of 11 case-control studies

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• 作者：Eyad M.A. Alshammari¹ ; Raju K. Mandal² ; Mohd Wahid² ; Sajad A. Dar² ; ³ ; Arshad Jawed² ; Mohammed Y. Areeshi² ; Saif Khan¹ ; Md. Ekhlaque Ahmed Khan⁴ ; Aditya K. Panda⁴ ; Shafiul Haque² ; ^{shafiul.haque@hotmail.com}
• 关键词：Genetic model ; Meta-analysis ; Polymorphism ; P2x7 gene ; Pulmonary tuberculosis
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：12
• 页码：1150-1157
• 全文大小：1549 K
• 卷排序：9

文摘

To summarize the precise association between pulmonary tuberculosis (PTB) and P2x7 A1513C gene polymorphism.MethodsPubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513C polymorphism and PTB risk. A meta-analysis was performed for the selected case–control studies and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models.ResultsEleven studies comprising 2 678 controls and 2 113 PTB cases were included in this meta-analysis. We observed overall no significant risk in all the five genetic models. When stratified population by the ethnicity, Caucasian population failed to show any risk of PTB in all the genetics models. In Asian ethnicity, variant allele (C vs. A: P = 0.001; OR = 1.375, 95% CI = 1.159–1.632) and heterozygous genotype (AC vs. AA: P = 0.001; OR = 1.570, 95% CI = 1.269–1.944) demonstrated significant increased risk of PTB. Likewise, recessive genetic model (CC + AC vs. AA: P = 0.001; OR = 1.540, 95% CI = 1.255–1.890) also demonstrated increased risk of PTB in Asians.ConclusionsOur meta-analysis did not suggest the association of P2x7 A1513C polymorphism with PTB risk in overall or separately in Caucasian population. However, it plays a significant risk factor for predisposing PTB in Asians. Future larger sample and expression studies are needed to validate this association.