文摘
First reported stability indicating method for the determination of related substances of acrivastine. Separation of geometrical isomer (Imp-III) in the same method. Identification, synthesis and characterization of new impurities by IR, NMR and LC/ESI–MSn. Forced degradation studies as per ICH guidelines. Method validation data shows that the method is highly sensitive, specific, selective, rugged and robust for the analysis.