Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents
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- 作者：Mingze Qina ; Shuang Yana ; Lei Wanga ; Haotian Zhangb ; Yanfang Zhaoa ; Shasha Wua ; Di Wua ; Ping Gonga ; gongpinggp@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diaryl ureas ; Organic synthesis ; Antitumor activity ; Structure-activity relationship
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：115
- 期：Complete
- 页码：1-13
- 全文大小：1482 K
文摘
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A series of novel diaryl ureas were identified as potent antitumor agents.
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Compound 13i potently suppressed proliferation of cancer cells.
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Compound 13i effectively inhibited c-Kit, RET, and FLT3 kinases.
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Compounds 13i significantly induced apoptosis of HT-29 cells.