Integrase with no cellular equivalent in host is a key enzyme in replication process of retrovirus.
3D-QSAR studies were performed on 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide derivatives.
3D-QSAR results were verified using molecular docking studies.
Validated models were used for designing new series of HIV-1 integrase inhibitor.