Biotransformation of the fungal neurotoxin Thomitrem A by primary rat hepatocytes

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• 作者：Christiane K. Fæ ; ste^a ; Angel Moldes-Anaya^b ; ^{angel.moldes-anaya@uit.no}
• 关键词：Biotransformation ; Rat hepatocytes ; Metabolites ; Prediction ; Thomitrem A ; Toxicokinetics
• 刊名：Toxicon
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：124
• 期：Complete
• 页码：36-43
• 全文大小：878 K
• 卷排序：124

文摘

The fungal neurotoxin Thomitrem A is metabolised by primary rat hepatocytes. Seven hepatic Thomitrem A metabolites were characterised by retention time and fragmentation patterns in LC-MS/MS analyses. Thomitrem A metabolites were products of oxidation and dehydration processes. Toxicokinetic parameters were derived from Thomitrem A depletion predicting a medium maximum bioavailability in rats.