The conserved molecular machinery in DNA mismatch repair enzyme structures
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- 作者：Flora S. Groothuizen ; Titia K. Sixma ; t.sixma@nki.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：MutS ; MutL ; MutH ; Structure conservation
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：14-23
- 全文大小：1752 K
文摘
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Structures of MMR proteins are highly conserved in evolution.
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Mismatch recognition by MutS homologs requires multiple ABC ATPase states.
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Signal transmission by MutL homologs requires multiple GHKL ATPase states.
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DNA cleavage by MutH or MutL homologs requires regulation at multiple levels.