Effect of fuel concentration on cargo transport by a team of Kinesin motors

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• 作者：Anjneya Takshak¹ ; Nirvantosh Mishra¹ ; Aditi Kulkarni ; Ambarish Kunwar ; ^{akunwar@iitb.ac.in}
• 关键词：Molecular motors ; Kinesin ; Mechano-chemical enzymes ; Monte-Carlo simulations
• 刊名：Physica A: Statistical Mechanics and its Applications
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：467
• 期：Complete
• 页码：395-406
• 全文大小：887 K
• 卷排序：467

文摘

A team of Kinesin motor proteins transports cellular cargos using ATP as fuel. How fuel concentration affects transport by the team largely remains unexplored. Mechano-chemical models of cargo transport developed here fill up this knowledge gap. Mechano-chemical models include effect of both force and fuel on cargo transport. Models predict very large cargo travel distances at limiting fuel concentrations. Models predict Michaelis-Menten dependence of cargo velocity on fuel concentration. These predictions from modeling can be directly tested by in-vitro experiments. Our results may be used to regulate and fine-tune transport by motor-based shuttles.