Molecularly imprinted polymers for simultaneous determination of antiepileptics in river water samples by liquid chromatography–tandem mass spectrometry
详细信息 查看全文
- 作者：Kaori Hoshina ; Shizuyo Horiyama ; Hisami Matsunaga ; Jun Haginaka
- 关键词：Restricted access media ; Molecularly imprinted polymer ; Sample preparation ; Liquid chromatography– ; tandem mass spectrometry ; Environmental analysis ; Cyclobarbital ; Phenobarbital ; Amobarbital ; Phenytoin
- 刊名：Journal of Chromatography A
- 出版年：2009
- 出版时间：19 June 2009
- 年：2009
- 卷：1216
- 期：25
- 页码：4957-4962
- 全文大小：312 K
文摘
A restricted access media–molecularly imprinted polymer (RAM–MIP) for cyclobarbital has been developed for selective extraction of antiepileptics in river water samples. The RAM–MIP was prepared using 4-vinylpyridine and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively, by a multi-step swelling and polymerization method followed by a surface modification technique. The RAM–MIP for cyclobarbital showed molecular recognition abilities for phenobarbital, amobarbital and phenytoin as well as cyclobarbital. Thus, selective analysis of antiepileptics in river water samples was attained with RAM–MIP extraction followed by column-switching liquid chromatography–tandem mass spectrometry. The concentrations of phenobarbital and phenytoin in river water samples were about 15 and 4 ng/L, respectively, while that of amobarbital was below the limit of quantitation.