Structural basis of efficient contagion: measles variations on a theme by parainfluenza viruses
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- 作者：Mathieu Mateo ; Chanakha K Navaratnarajah ; Roberto Cattaneo cattaneo.roberto@mayo.edu" class="auth_mail
- 刊名：Current Opinion in Virology
- 出版年：April 2014
- 年：2014
- 卷：5
- 期：Complete
- 页码：16-23
- 全文大小：2337 K
文摘
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The 尾-propeller head of the wild type measles virus hemagglutinin binds exclusively two tissue-specific receptors.
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The signaling lymphocytic activation molecule (SLAM) and the epithelial receptor nectin-4 bind adjacent surfaces of the hemagglutinin head.
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A mutated hydrophobic groove of the vaccine strain hemagglutinin binds the ubiquitous protein CD46, a decoy receptor.
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Specificity domains added to the hemagglutinin can target viral entry to designated receptors expressed on cancer cells.