Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons
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- 作者：Lauren E. Cornelison ; Jordan L. Hawkins ; Paul L. Durham ; pauldurham@missouristate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CGRP ; calcitonin gene-related peptide ; GFAP ; glial fibrillary acidic protein ; Iba1 ; ionized calcium-binding adapter molecule 1 ; MAP ; mitogen-activated protein ; PBS ; phosphate-buffered saline ; P-ERK ; phosphorylated extracellular signal-regulated kinase ; PKA ; protein kinase A ; S.E.M. ; standard error of the mean ; TMD ; temporomandibular disorder ; TMJ ; temporomandibular joint
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：491-501
- 全文大小：1943 K
文摘
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Intrathecal CGRP promotes sensitization of primary trigeminal nociceptive neurons.
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10">Stimulatory effects of CGRP are mediated by PKA and involve astrocyte activation.
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15">CGRP-dependent behavioral changes associate with increased P-ERK levels in ganglion.
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Elevated CGRP levels in spinal cord promote neuron-glia communication in ganglion.
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Our results provide direct evidence of bidirectional signaling within trigeminal system.