Are glutamate and lactate increases ubiquitous to physiological activation? A ¹H functional MR spectroscopy study during motor activation in human brain at 7 Tesla

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• 作者：Benoî ; t Schaller^a ; ^{benoit.schaller@cardiov.ox.ac.uk" class="auth_mail} ; Lijing Xin^b ; ^{lijing.xin@epfl.ch" class="auth_mail} ; Kieran O'Brien^c ; ^{kieran.obrien@epfl.ch" class="auth_mail} ; Arthur W. Magill^a ; ^b ; ^{a.magill@fz-juelich.de" class="auth_mail} ; Rolf Gruetter^a ; ^b ; ^d ; ^{rolf.gruetter@epfl.ch" class="auth_mail}
• 关键词：Asp ; aspartate ; Cerebral metabolic rate ; CMR ; CRLB ; Cramé ; r&ndash ; Rao lower bounds ; Cr ; creatine ; tCho ; total choline ; FASTMAP ; fast automatic shimming technique by mapping along the projections ; Functional magnetic resonance imaging ; fMRI ; Functional magnetic resonance spectroscopy ; fMRS ; GABA ; 纬-aminobutyric acid ; Gln ; glutamine ; Glu ; glutamate ; GSH ; glutathione ; Ins ; myo-inositol ; Lac ; lactate ; tNAA ; total NAA ; NAA ; N-acetylaspartate ; NAAG ; N-acetylaspartylglutamate ; NT ; number of tran
• 刊名：NeuroImage
• 出版年：June, 2014
• 年：2014
• 卷：93
• 期：part_P1
• 页码：138-145
• 全文大小：859 K

文摘

Recent studies at high field (7 Tesla) have reported small metabolite changes, in particular lactate and glutamate (below 0.3 渭mol/g) during visual stimulation. These studies have been limited to the visual cortex because of its high energy metabolism and good magnetic resonance spectroscopy (MRS) sensitivity using surface coil. The aim of this study was to extend functional MRS (fMRS) to investigate for the first time the metabolite changes during motor activation at 7 T. Small but sustained increases in lactate (0.17 渭mol/g 卤 0.05 渭mol/g, p < 0.001) and glutamate (0.17 渭mol/g 卤 0.09 渭mol/g, p < 0.005) were detected during motor activation followed by a return to the baseline after the end of activation. The present study demonstrates that increases in lactate and glutamate during motor stimulation are small, but similar to those observed during visual stimulation. From the observed glutamate and lactate increase, we inferred that these metabolite changes may be a general manifestation of the increased neuronal activity. In addition, we propose that the measured metabolite concentration increases imply an increase in 螖CMR_O2 that is transiently below that of 螖CMR_Glc during the first 1 to 2 min of the stimulation.