SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia
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- 作者：Simon Glerup1 ; 2 ; 3 ; sg@biokemi.au.dk" class="auth_mail ; Ditte Olsen1 ; 2 ; Christian B. Vaegter1 ; 2 ; Camilla Gustafsen1 ; 2 ; Susanne S. Sjoegaard1 ; 2 ; Guido Hermey1 ; 4 ; Mads Kjolby1 ; 2 ; Simon Molgaard1 ; 2 ; 5 ; Maj Ulrichsen1 ; 2 ; Simon Boggild1 ; 2 ; Sune Skeldal1 ; Anja N. Fjorback1 ; 2 ; Jens R. Nyengaard5 ; Jan Jacobsen6 ; Dirk Bender6 ; Carsten R. Bjarkam7 ; Esben S. Sø ; rensen8 ; Ernst-Martin Fü ; chtbauer8 ; Gregor Eichele9 ; Peder Madsen1 ; Thomas E. Willnow10 ; Claus M. Petersen1 ; Anders Nykjaer1 ; 2 ; 3 ; an@biokemi.au.dk" class="auth_mail
- 刊名：Neuron
- 出版年：4 June 2014
- 年：2014
- 卷：82
- 期：5
- 页码：1074-1087
- 全文大小：8450 K
文摘
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SorCS2 is a single-chain receptor in CNS neurons but is cleaved into a two-chain variant in PNS glia
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Single-chain SorCS2 is required for growth cone collapse in CNS neurons
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Two-chain SorCS2 is critical for Schwann cell apoptosis following peripheral injury
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SorCS2 knockouts display dopaminergic hyperinnervation and an ADHD-like behavior