An efficient method for the lipase-catalysed resolution and in-line purification of racemic flurbiprofen in a continuous-flow reactor

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• 作者：Lucia Tamborini ; Diego Romano ; Andrea Pinto ; Arianna Bertolani ; Francesco Molinari ; Paola Conti
• 关键词：Enzymatic resolution ; Flow reactor ; Lipase ; Flurbiprofen ; Catch and release
• 刊名：Journal of Molecular Catalysis B: Enzymatic
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：84
• 期：Complete
• 页码：78-82
• 全文大小：298 K

文摘

The lipase-catalysed kinetic resolution of flurbiprofen was performed in a flow-chemistry reactor allowing for a significant reduction of the reaction time compared to the classical batch method. The process was implemented by adding an in-line purification step of the exiting solution, consisting in a catch and release protocol, which allows easy separation and recovery of both (S)-flurbiprofen and (R)-flurbiprofen butyl ester with an enantiomeric excess ¡Ý90 % and a chemical purity >98 % .