Biotransformation with whole microbial systems in a continuous flow reactor: resolution of (RS)-flurbiprofen using Aspergillus oryzae by direct esterification with ethanol in organic solvent

详细信息    查看全文

• 作者：Lucia Tamborini ; Diego Romano ; Andrea Pinto ; Martina Contente ; Maria C. Iannuzzi ; Paola Conti ; Francesco Molinari
• 关键词：Enzymatic resolution ; Dry mycelia ; Flow reactor ; Flurbiprofen ; Aspergillus oryzae
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：6 November, 2013
• 年：2013
• 卷：54
• 期：45
• 页码：6090-6093
• 全文大小：457 K

文摘

Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the enantioselectivity were achieved compared to the batch mode. Moreover, the process was implemented by adding an in-line purification step integrated with the racemization of the unreacted flurbiprofen directly into a polymer-supported resin.