Prevalence and factors involved in discordant responses to highly active antiretroviral treatment in a closely followed cohort of treatment-na????ve HIV-infected patients

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• 作者：Molina-Pinelo ; Sonia ; Leal ; Manuel ; Soriano-Sarabia ; Natalia ; Guti??rrez ; Sonia ; Fernandez ; Ger??nimo ; et. al.
• 关键词：HAART ; Naï ; ve ; Thymic volume ; TREC ; Treatment compliance
• 刊名：Journal of Clinical Virology
• 出版年：2005
• 出版时间：June, 2005
• 年：2005
• 卷：33
• 期：2
• 页码：110-115
• 全文大小：121 K

文摘

The prevalence and the factors involved in discordant responses to highly active antiretroviral therapy were analysed in a closely followed cohort of 51 naïve HIV-infected patients at 48 weeks.

A complete treatment response was considered as an increase in CD4 cell count of ≥50 cells/mm<sup>3sup> with a ≥1 log<sub>10sub> decrease in viral load or viral suppression. Virologic response (<50 CD4<sup>+sup> cells/mm<sup>3sup> increase) and immune response (<1 log<sub>10sub> decrease in viral load) were observed in 15.7 % and 5.8 % of the patients, respectively.

We demonstrated that the prevalence of virologic response decreased at week 72 and disappeared after 96 weeks of treatment. This slower CD4 repopulation correlated with a lower thymic volume compared to those with complete response. Also, the probability of having virologic response did not correlate with protease inhibitor-based (PI-based) regimens or HCV coinfection. On the other hand, immune response in our cohort could be easily attributable to a simple mechanism, i.e. irregular treatment compliance.