A comparison of the effects of three different luteal phase support protocols on in vitro fertilization outcomes: a randomized clinical trial

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• 作者：Turgut Var ; Esra Ayş ; in Tonguc ; Melike Doğ ; anay ; Cavidan Gulerman ; Tayfun Gungor ; Leyla Mollamahmutoglu
• 关键词：Luteal phase support ; progesterone ; estradiol ; hCG ; luteal phase hormone profile ; ICSI ; pregnancy rate
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：1 March 2011
• 年：2011
• 卷：95
• 期：3
• 页码：985-989
• 全文大小：105 K

文摘

Objective

To evaluate the effects of three different luteal phase support protocols on pregnancy and implantation rates, as well as luteal phase hormone profile in intracytoplasmic sperm injection–ET cycles.

Design

A prospective, randomized study.

Setting

A tertiary teaching and research hospital.

Patient(s)

Two hundred eighty-eight patients who were undergoing intracytoplasmic sperm injection with a long protocol of controlled ovarian hyperstimulation.

Intervention(s)

Group 1 (E₂ + P) received daily P plus 4 mg of E₂, group 2 (hCG + P) received P plus 1,500 IU of hCG, and group 3 (P only) received daily vaginal P gel. Blood samples were drawn on the day of hCG administration, as well as 7 and 10 days after the hCG for the E₂ and P measurements.

Main Outcome Measure(s)

The clinical pregnancy rate.

Result(s)

No difference existed between the E₂ + P and hCG + P groups with respect to pregnancy rate, but it was significantly lower in the P-only group.The implantation rate was significantly lower in the P-only group than in the other groups.The highest miscarriage rate was in the P-only group (38 % ).

Conclusion(s)

In assisted reproductive technology cycles including treatment with GnRH agonist, adding 4 mg of oral E₂ to P during the luteal phase significantly increased the pregnancy and implantation rates and decreased the miscarriage rate compared with the use of P only.