Effect of compressive force on the expression of inflammatory cytokines and their receptors in osteoblastic Saos-2 cells

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• 作者：Yuki Koyama ; Narihiro Mitsui ; Naoto Suzuki ; Momoko Yanagisawa ; Rina Sanuki ; Keitaro Isokawa ; Noriyoshi Shimizu ; Masao Maeno
• 关键词：Cytokine receptors ; Inflammatory cytokines ; Mechanical stress ; Orthodontic tooth movement
• 刊名：Archives of Oral Biology
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：53
• 期：5
• 页码：488-496
• 全文大小：1304 K

文摘

In orthodontic tooth movement, some cytokines released from periodontal ligament fibroblasts and alveolar bone osteoblasts on the pressure side can alter the normal processes of bone remodelling, resulting in physiological bone resorption. We examined the effect of compressive force and interleukin (IL)-1 type I receptor antagonist (IL-1ra) on the expression of inflammatory cytokines that promote osteoclast formation, as well as on their receptors, in osteoblastic Saos-2 cells.