Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation
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- 作者：Tomonori Kato ; Seitaro Terakura ; Makoto Murata ; Kyoko Sugimoto ; Miho Murase ; Chisako Iriyama ; Akihiro Tomita ; Akihiro Abe ; Momoko Suzuki ; Tetsuya Nishida ; Tomoki Naoe
- 关键词：Cytotoxic T lymphocyte ; HLA ; Immune escape
- 刊名：Cellular Immunology
- 出版年：2012
- 出版时间：March-April, 2012
- 年：2012
- 卷：276
- 期：1-2
- 页码：75-82
- 全文大小：674 K
文摘
A case of leukemia escape from an HLA-specific cytotoxic T lymphocyte (CTL) response in a recipient of bone marrow transplantation is presented. Only the expression of HLA-B51, which was a mismatched HLA locus in the graft-versus-host direction, was down-regulated in post-transplant leukemia blasts compared with that in pre-transplant blasts. All CTL clones, that were isolated from the recipient¡¯s blood when acute graft-versus-host disease developed, recognized the mismatched B?51:01 molecule in a peptide-dependent manner. The pre-transplant leukemia blasts were lysed by CTL clones, whereas the post-transplant leukemia blasts were not lysed by any CTL clones. The IFN-¦Ã ELISPOT assay revealed that B?51:01-reactive T lymphocytes accounted for the majority of the total alloreactive T lymphocytes in the blood just before leukemia relapse. These data suggest that immune escape of leukemia blasts from CTL pressure toward a certain HLA molecule can lead to clinical relapse after bone marrow transplantation.