Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention

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• 作者：Tina Heinz^a ; ^{heinz@nutrition.uni-hannover.de" class="auth_mail" title="E-mail the corresponding author} ; Jan Philipp Schuchardt^a ; Katharina Mö ; ller^a ; Peyman Hadji^b ; Andreas Hahn^a ; ^{hahn@nutrition.uni-hannnover.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：LDL-cholesterol ; Red yeast rice ; Monacolin K ; Homocysteine ; Folic acid
• 刊名：Nutrition Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：36
• 期：10
• 页码：1162-1170
• 全文大小：404 K

文摘

Hypercholesterolemia and elevated homocysteine concentrations are associated with cardiovascular risk. Previous studies have demonstrated a cholesterol-lowering effect of red yeast rice (RYR) supplements which contained 5 to 10 mg of monacolin K. We hypothesized that the intake of a low monacolin K dose may likewise reduce low-density lipoprotein–cholesterol (LDL-C) and other plasma lipids. In secondary analyses, we tested the homocysteine lowering effect of folic acid, which was also included in the study preparation. Therefore, we conducted a randomized, double-blind, and placebo-controlled intervention study. One hundred forty-two nonstatin-treated participants with hypercholesterolemia (LDL-C ≥ 4.14 ≤ 5.69 mmol/L) were randomized to the supplement group with RYR or the placebo group. Participants of the supplement group consumed 3 mg monacolin K and 200 μg folic acid per day. A significant (P < .001) reduction of LDL-C (−14.8%), total cholesterol (−11.2%), and homocysteine (−12.5%) was determined in the supplement group after 12 weeks. A total of 51% of the participants treated with RYR achieved the limit of LDL-C <4.14 mmol/L advised and 26% reached the threshold level of homocysteine <10 μmol/L. No significant changes were exhibited within the placebo group. Other parameters remained unchanged and no intolerances or serious adverse events were observed. In conclusion, we demonstrated that a low dose of daily 3 mg monacolin K from RYR reduces the concentration of LDL-C; a risk factor for cardiovascular diseases.