Amberlite–IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products

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• 作者：Abhijit Hazra ; Shyamal Mondal ; Arindam Maity ; Subhendu Naskar ; Pritam Saha ; Rupankar Paira ; Krishnendu B. Sahu ; Priyankar Paira ; Soma Ghosh ; Ch ; rima Sinha ; Amalesh Samanta ; Sukdeb Banerjee ; Nirup B. Mondal
• 关键词：Indolizines ; Pyrrolo quinolines/isoquinolines ; Amberlite– ; IRA-402 (OH) ; Dipolar cycloaddition ; Antibacterial ; Antifungal
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：46
• 期：6
• 页码：2132-2140
• 全文大小：1366 K

文摘

A number of indolizines and pyrrolo[1,2-a]quinolines/isoquinolines were prepared from phenacyl pyridinium, quinolinium and isoquinolinium salts derived fromthe reaction of the heterocycles with 2-bromo acetophenone with alkynes and alkenes using amberlite–IRA-402 (OH) ion exchange resin as the base. Antibacterial and antifungal studies were carried out against thirteen bacterial and four fungal strains, which revealed that three derivatives (4a, 4b, 7a) out of fifteen are effective against all the thirteen strains and one derivative, 10, showed dual antibactericidal and antifungal efficacy.