Rapid, efficient and solvent free microwave mediated synthesis of aldo- and ketonitrones

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• 作者：Loredana Maiuolo^a ; ^{maiuolo@unical.it" class="auth_mail" title="E-mail the corresponding author} ; Antonio De Nino^a ; ^{denino@unical.it" class="auth_mail" title="E-mail the corresponding author} ; Pedro Merino^b ; Beatrice Russo^a ; Gaetano Stabile^a ; Monica Nardi^a ; Napoleone D&rsquo ; Agostino^a ; Tatiana Bernardi^c
• 关键词：Aldonitrones ; 1 ; 3-Dipoles ; Ketonitrones ; Microwave ; Neat reactions
• 刊名：Arabian Journal of Chemistry
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：9
• 期：1
• 页码：25-31
• 全文大小：1440 K

文摘

A library of C-alkyl and C-aryl nitrones has been obtained by direct condensation of primary N-substituted hydroxylamine hydrochlorides with various aldehydes and ketones without catalysts or base. The synthetic procedure, performed under MW irradiation in the absence of solvent, does not require the presence of a base, is fast, clean, high-yielding and characterized by simple work-up.