The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses
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- 作者：Margarita C. Dinamarcaa ; 1 ; Monica Di Lucab ; Juan A. Godoya ; Nibaldo C. Inestrosaa ; c ; d ; e ; ninestrosa@bio.puc.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroligin-1 ; Aβ oligomer ; Excitatory synapses ; Hippocampal neurons
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：9 October 2015
- 年：2015
- 卷：466
- 期：1
- 页码：66-71
- 全文大小：1211 K
文摘
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Amyloid-β oligomers (Aβo) play a major role in the synaptic dysfunction of Alzheimer's disease.
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Neuroligin-1 facilitates the targeting of Aβo to the postsynaptic region of excitatory synapses.
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Aβo are associated with neuroligin-1 at excitatory synapses in hippocampal neurons.
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The soluble extracellular fragment of neuroligin-1 protects synapses in neurons damaged by Aβo.
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Soluble neuroligin-1 protect against Aβo-damage of field excitatory postsynaptic potentials.