Signaling scaffolds in immune cells

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• 作者：J. S. Kennedy ; Monika Raab ; C. E. Rudd
• 关键词：Ca²⁺ signals ; IP₃ ; SH-SY5Y cells
• 刊名：Cell Calcium
• 出版年：1999
• 出版时间：November 1999
• 年：1999
• 卷：26
• 期：5
• 页码：227-235
• 全文大小：322 K

文摘

Of the past several years progress in understanding TCR signal transduction has led to the discovery of new kinases, adapter molecules and multiple signaling pathways. The study of molecules such as LAT, SLP-76, FYB, SKAP-55 and VAV have revealed multiple mechanisms with which to control the activation of downstream signaling pathways through RAS, PLC_γ-1 and ERK/MAPK. Signaling through SLP-76 can play a role in TCR-induced cytoskeleton changes through activation of effector molecules in the RAC/RHO-family of GTPases. In addition, SLP-76 through its association with FYB/FYN-T appears to play a role in IL-2 gene transcription following TCR activation. Finally, these newly identified adaptor molecules, such as LAT, may be crucial in T-cell activation by enhancing the recruitment of critical kinases to glycolipid-enriched microdomains of the activated T-cell receptor complex.