Relevance and challenges in modeling human gastric and small intestinal digestion

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• 作者：Aur¨¦lie Guerra ; Lucie Etienne-Mesmin ; Val¨¦rie Livrelli ; Sylvain Denis ; St¨¦phanie Blanquet-Diot ; Monique Alric
• 关键词：human digestion ; stomach and small intestine ; in vitro models
• 刊名：Trends in Biotechnology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：30
• 期：11
• 页码：591-600
• 全文大小：1373 K

文摘

Gastric and small intestinal (GSI) models are increasingly used as an alternative to in vivo assays to answer many questions raised by industry and researchers. A broad range of in vitro systems is available, from static monocompartmental to dynamic multicompartmental models. However, these models require a compromise between technological complexity and biological significance. Further efforts and technological innovations are still needed to improve in vitro models and meet growing demands in the areas of nutrition and health. This review describes the models available to date for the human stomach and small intestine and highlights their relevance in nutritional, toxicological, pharmaceutical, and microbiological studies. Limitations and challenges facing artificial digestion technology are also discussed.