Critical elements for human health risk assessment of less than lifetime exposures

详细信息    查看全文

• 作者：Liesbeth Geraets ; Monique M. Nijkamp ; Wouter ter Burg ; ^{wouter.ter.burg@rivm.nl}
• 关键词：Risk assessment ; Less than lifetime exposure ; Fluctuating exposure ; Intermittent exposure
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：81
• 期：Complete
• 页码：362-371
• 全文大小：415 K
• 卷排序：81

文摘

Guidance to deal with less than lifetime exposure in risk assessment is presented. Critical elements such as toxicokinetics in risk assessment of less than lifetime exposure are explained. The approach is exemplified by considering case studies of less than lifetime exposure. The approach illustrates that substance specific information is required for refinement of the risk assessment.