The osteopontin-controlled switching of calcium oxalate monohydrate morphologies in artificial urine provides insights into the formation of papillary kidney stones
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- 作者：Aaron Langdona ; 1 ; langdo7@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bernd Grohea ; b ; bgrohe@uwo.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteopontin ; Artificial urine ; Calcium oxalate ; Physicochemical conditions ; Protein incorporation ; Crystal morphology switching ; Papillary kidney stones
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：296-306
- 全文大小：2485 K
文摘
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Osteopontin (OPN) induces abrupt switching of morphologies in kidney stone-related calcium oxalate monohydrate (COM).
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Transformation from facetted hyper twins to textured dumbbells occurs without intermediate habits.
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Synthesized hyper twins and dumbbells resemble habits in the mantle and core of papillary kidney stones.
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Evidence suggests that OPN is the strongest proteomic effector of COM formation in the urinary tract.