RP-HPLC detection and dosage method for acrylic monomers and degradation products released from implanted medical devices
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- 作者：Lionel Tortolanoa ; b ; lionel.tortolano@u-psud.fr" class="auth_mail" title="E-mail the corresponding author ; Senda Hammamia ; Katia Manerlaxa ; Bernard Doa ; c ; Najet Yagoubia
- 关键词：Medical devices ; RP-HPLC ; Polymer ; Acrylic monomers ; Cytotoxicity
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：1038
- 期：Complete
- 页码：26-33
- 全文大小：1324 K
文摘
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Acrylic polymers released degradation products under oxidative and heating conditions.
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We present a RP-HPLC method for detection of acrylics degradation products.
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The method is efficient for polar and nonpolar compounds detection in saline matrices.
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Application on intraocular lenses confirmed the release of polar degradation products.