Evaluation of DNA-damaging potential of bisphenol A and its selected analogs in human peripheral blood mononuclear cells (in vitro study)

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• 作者：Katarzyna Mokra^a ; Agnieszka Kuźmińska-Surowaniec^a ; Katarzyna Woźniak^b ; Jaromir Michałowicz^a ; ^{michalow@biol.uni.lodz.pl}
• 关键词：Bisphenol A ; Bisphenol A analogs ; Comet assay ; DNA damage ; DNA repair ; PBMCs
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：62-69
• 全文大小：590 K
• 卷排序：100

文摘

Effect of BPA and its selected analogs on DNA damage and repair in PBMCs was studied. BPAF induced the strongest DNA single strand-breaks and double strand-breaks in PBMCs. BPS, which is main substituent of bisphenol A caused much lower DNA damage than BPA. PBMCs significantly repaired bisphenols-induced DNA damage. BPA and BPAF at low concentration of 0.01 μg/ml were able to induce single strand-breaks.