Initial investigations of C4a-(hydro)peroxyflavin intermediate formation by dibenzothiophene monooxygenase
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- 作者：Liliana Gonzalez-Osorioa ; Kelvin Luonga ; 1 ; Samatar Jirdea ; Bruce A. Palfeyb ; c ; Jessica L. Veya ; jessica.vey@csun.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavin monooxygenase ; Flavin hydroperoxide ; Dibenzothiophene ; Biodesulfurization
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：481
- 期：1-2
- 页码：189-194
- 全文大小：1022 K
文摘
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Dibenzothiophene monooxygenase forms and stabilizes a C4a-peroxyflavin intermediate.
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S163 and H391 are required for stabilization of the peroxyflavin intermediate.
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H391's positive charge is likely involved in catalyzing the flavin - oxygen reaction.
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S163 likely stabilizes the peroxyflavin to elimination of hydrogen peroxide.