Sustained delivery of chondroitinase ABC by poly(propylene carbonate)-chitosan micron fibers promotes axon regeneration and functional recovery after spinal cord hemisection
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- 作者：Shilei Nia ; 1 ; Tongliang Xiaa ; 1 ; Xingang Lia ; Xiaodong Zhua ; Hongxu Qib ; Shanying Huangc ; Jiangang Wanga ; drwjg@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PPC ; polypropylene carbonate ; dbcAMP ; dibutyryl cyclic adenosine monophosphate ; SCI ; spinal cord injury ; CO2 ; carbon dioxide ; SEM ; scanning electron microscopy ; GAP-43 ; growth-associated protein 43 ; NF-200 ; neurofilament-200 ; GFAP ; glial fibrillary acidic protein ; BBB ; Basso ; Beattie ; and Bresnahan ; ChABC ; chondroitin sulfate ABC ; CSPGs ; chondroitin sulfate proteoglycans ; CS ; chitosan ; PVP ; polyvinylpyrrolidone ; GAG ; glycosaminoglycan ; CS-56 ; anti-chondroitin sulfate.
- 刊名：Brain Research
- 出版年：2015
- 出版时间：22 October 2015
- 年：2015
- 卷：1624
- 期：Complete
- 页码：469-478
- 全文大小：10390 K
文摘
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The PPC-CS micron fibers could be used for the local sustained delivery of agents in SCI.
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Locally released ChABC could stimulate axon growth into the glial scar.
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Locally released ChABC could reduce the glial scar formation after SCI.
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Locally sustained delivery of ChABC could promote the recovery of motor function after SCI.