E3-Independent Constitutive Monoubiquitination Complements Histone Methyltransferase Activity of SETDB1
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- 作者：Lidong Sun1 ; Jia Fang1 ; Jia.Fang@moffitt.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：62
- 期：6
- 页码：958-966
- 全文大小：1938 K
文摘
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SETDB1 is monoubiquitinated at lysine-867 (K867Ub1)
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SETDB1-K867Ub1 is directly catalyzed by UBE2E enzymes independent of E3 ligase
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Conjugated-ubiquitin on K867 is protected from deubiquitination by SETDB1 domains
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K867Ub1 is essential for SETDB1’s enzymatic activity and function