The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
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- 作者：Eeson Rajendra1 ; Vibe H. Oestergaard1 ; 3 ; Fré ; dé ; ric Langevin1 ; Meng Wang1 ; 4 ; Gillian L. Dornan1 ; Ketan J. Patel1 ; 2 ; kjp@mrc-lmb.cam.ac.uk" class="auth_mail ; Lori A. Passmore1 ; passmore@mrc-lmb.cam.ac.uk" class="auth_mail
- 刊名：Molecular Cell
- 出版年：5 June 2014
- 年：2014
- 卷：54
- 期：5
- 页码：858-869
- 全文大小：1838 K
文摘
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A native Fanconi anaemia core complex is purified from vertebrate cells
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Purified FA core complex monoubiquitinates FANCD2 in vitro
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FANCB, FANCL, and FAAP100 constitute the minimal monoubiquitination module
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Other subunits contribute to maximal activity and site specificity of FANCL