HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H
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- 作者：Guangyi Wang ; Huoxing Lei ; Xiaofang Wang ; Debasis Das ; Jian Hong ; Colin H. Mackinnon ; Thomas S. Coulter ; Christian A.G.N. Montalbetti ; Richard Mears ; Xinjie Gai ; Sarah E. Bailey ; Donald Ruhrmund ; Lisa
- 关键词：Benzothiadiazine ; HCV NS5B polymerase inhibitors
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 August 2009
- 年：2009
- 卷：19
- 期：15
- 页码：4480-4483
- 全文大小：433 K
文摘
(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.